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Stem Cells for Pancreatic Cancer Manchester NH

New research is moving scientists closer to their goal of treating pancreatic cancer by killing tumors without hurting healthy tissue. The researchers, who were scheduled to report their findings at the American College of Surgeons Clinical Congress, Oct. 11-15 in Chicago, have created a bioengineered "construct" that uses stem cells derived from bone marrow and a genetic product that stops tumor growth.

Charles George Leutzinger, MD
(603) 628-1800
1 Elliot Way
Manchester, NH
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Univ Of Ct Sch Of Med, Farmington Ct 06032
Graduation Year: 1976

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Donald Raabe Weiss, MD
(603) 663-1800
1 Elliot Way
Manchester, NH
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Languages
Other
Education
Medical School: Univ Of Co Sch Of Med, Denver Co 80262
Graduation Year: 1965
Hospital
Hospital: St Joseph Hospital And Trauma, Nashua, Nh; Elliot Hosp, Manchester, Nh; Concord Hosp, Concord, Nh; Wentworth-Douglass Hospital, Dover, Nh; Exeter Hosp, Exeter, Nh
Group Practice: Elliot Regional Cancer Ctr

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Karen Jane Hoffmeister
(603) 629-1827
100 Hitchcock Way
Manchester, NH
Specialty
Hematology / Oncology

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Danny M Sims
(603) 622-6484
200 Technology Dr
Hooksett, NH
Specialty
Hematology / Oncology

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Michael S Buff
(603) 622-6484
200 Technology Drive
Hooksett, NH
Specialty
Internal Medicine, Hematology / Oncology

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Brian Robert Knab
(603) 663-1800
1 Elliot Way
Manchester, NH
Specialty
Radiation Oncology

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Thomas Andrew Sheldon, MD
(603) 669-5300
1 Elliot Way
Manchester, NH
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Tufts Univ Sch Of Med, Boston Ma 02111
Graduation Year: 1980
Hospital
Hospital: Elliot Hosp, Manchester, Nh
Group Practice: New Hampshire Medical Lab

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Jack Terry Evjy, MD
(978) 685-7811
21 Bowman Parade Rd
Bedford, NH
Specialties
Oncology (Cancer), Hematology-Internal Medicine
Gender
Male
Education
Medical School: Boston Univ Sch Of Med, Boston Ma 02118
Graduation Year: 1961
Hospital
Hospital: Holy Family Hosp And Med Ctr, Methuen, Ma
Group Practice: Commonwealth Hematology-Onclgy

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Robert J Friedlander
(603) 622-6484
200 Technology Dr
Hooksett, NH
Specialty
Hematology / Oncology

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Robert J Friedlander Jr, MD
(603) 622-6484
200 Technology Dr
Hooksett, NH
Specialties
Oncology (Cancer)
Gender
Male
Education
Medical School: Cornell Univ Med Coll, New York Ny 10021
Graduation Year: 1981
Hospital
Hospital: Elliot Hosp, Manchester, Nh; Lakes Region General Hospital, Laconia, Nh
Group Practice: New Hampshire Oncology

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Stem Cells for Pancreatic Cancer

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WEDNESDAY, Oct. 14 (HealthDay News) -- New research is moving scientists closer to their goal of treating pancreatic cancer by killing tumors without hurting healthy tissue.

The researchers, who were scheduled to report their findings at the American College of Surgeons Clinical Congress, Oct. 11-15 in Chicago, have created a bioengineered "construct" that uses stem cells derived from bone marrow and a genetic product that stops tumor growth.

Pancreatic cancer requires stem cells in order to grow. The "Trojan horse" created by the researchers essentially confuses cancer cells and makes them produce a toxic product.

The findings could in time lead to better treatments for pancreatic cancer, which is often fatal. According to the National Cancer Institute, 43,000 people in the United States are diagnosed with the disease each year, and 35,000 people die.

"The prognosis of advanced pancreatic cancer is so devastating that even a small effect on prolongation and quality of life would be a tremendous outcome for the patient," study author Dr. Claudius Conrad of Massachusetts General Hospital in Boston, said in a news release from the American College of Surgeons.

One currently available treatment is chemotherapy, but it can make healthy cells become sick and can cause a variety of side effects, including bowel damage, diarrhea and nausea.

"We developed our concept of using stem cells to target tumor cells because the homing drive of aggressive tumors like pancreatic cancer is so strong that genetically engineered stem cells can help destroy the tumor," Conrad explained. "Also, the unique signals in the tumor microenvironment can help make the therapy cancer-specific once the modified stem cells have been homed."

To date, the research is still in preliminary stages and has been tested only in animals.

More information

Learn more about pancreatic cancer from the U.S. National Cancer Institute.

SOURCE: American College of Surgeons, news release, Oct. 14, 2009

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