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Side Effects in Statin Users Linked to Gene Mutation Nashua NH

U.S. researchers have identified a common gene mutation linked to side effects in people taking cholesterol-lowering statin drugs. Statins can reduce high cholesterol and lower the risk of heart attack or stroke. But 25 percent to 50 percent of people prescribed the potentially lifesaving drugs stop taking them after a year because of side effects, in particular muscle aches.

Steven Lee Schwartz, MD
(603) 577-2039
PO Box 1184
Nashua, NH
Specialties
Cardiology, Internal Medicine
Gender
Male
Education
Medical School: Suny-Hlth Sci Ctr At Brooklyn, Coll Of Med, Brooklyn Ny 11203
Graduation Year: 1984
Hospital
Hospital: Lahey Clinic, Burlington, Ma; Southern New Hampshire Regiona, Nashua, Nh
Group Practice: Lahey Cardiology

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Steven Paul Beaudette, MD
(603) 883-5673
166 Kinsley St
Nashua, NH
Specialties
Cardiology
Gender
Male
Education
Medical School: Tufts Univ Sch Of Med, Boston Ma 02111
Graduation Year: 1988

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William Timothy Larney, MD
(603) 579-9631
280 Main St
Nashua, NH
Specialties
Cardiology
Gender
Male
Education
Medical School: New York Med Coll, Valhalla Ny 10595
Graduation Year: 1974

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Mark Joel Liebling, MD
(603) 883-5673
166 Kinsley St Ste 301
Nashua, NH
Specialties
Cardiology
Gender
Male
Education
Medical School: A Einstein Coll Of Med Of Yeshiva Univ, Bronx Ny 10461
Graduation Year: 1975

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Steven L Schwartz
(603) 577-2039
8 Prospect St
Nashua, NH
Specialty
Cardiology, Internal Medicine, Cardiovascular Disease

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Wendi A Cardeiro, MD, FACC
(603) 577-2039
PO Box 1184
Nashua, NH
Specialties
Cardiology
Gender
Male
Education
Graduation Year: 2007

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Christopher Thomas Pyne, MD
(617) 273-8546
21 E Hollis St
Nashua, NH
Specialties
Cardiology
Gender
Male
Education
Medical School: Hahnemann Univ Sch Of Med, Philadelphia Pa 19102
Graduation Year: 1987

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Yuka Endo
(603) 577-2039
8 Prospect St # 1184
Nashua, NH
Specialty
Cardiovascular Disease

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Paul Francis Boffetti
(603) 577-2780
8 Prospect St
Nashua, NH
Specialty
Cardiology, Internal Medicine

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Dr.Yuka Endo
(603) 577-2039
8 Prospect Street
Nashua, NH
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F
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Cardiologist
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Side Effects in Statin Users Linked to Gene Mutation

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WEDNESDAY, Oct. 14 (HealthDay News) -- U.S. researchers have identified a common gene mutation linked to side effects in people taking cholesterol-lowering statin drugs.

Statins can reduce high cholesterol and lower the risk of heart attack or stroke. But 25 percent to 50 percent of people prescribed the potentially lifesaving drugs stop taking them after a year because of side effects, in particular muscle aches.

The study included 509 people taking one of three types of statins: atorvastatin (Lipitor), simvastatin (Zocor) or pravastatin (Pravachol). The patients took the drugs for an initial period of eight weeks and then had their doses increased for an additional eight weeks.

The Duke University Medical Center researchers found that people with the common mutation in the SLCO1B1 gene were more likely to have muscle aches. The more copies of the mutation, the greater their risk.

The study also found that the muscle side effects differed depending on the type of statin. People taking simvastatin reported the most side effects while those taking pravastatin had the least muscle aches.

The findings, published online Oct. 12 in the Journal of the American College of Cardiology, may help doctors increase the number of patients who keep taking the drugs.

"If a genetic test can be developed to determine who will experience side effects that will likely make patients go off their medication, we can target these individuals for counseling about common side effects, monitor them more closely or tailor their medication accordingly," lead author and cardiologist Dr. Deepak Voora said in a Duke news release.

More information

The U.S. Food and Drug Administration has more about statins.

SOURCE: Duke Medicine, news release, Oct. 12, 2009

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