The Hippo

HOME| ADVERTISING | CONTACT US|

Nicotine Receptors Could Be Lung Cancer Treatment Target Concord NH

In a study of mice with lung cancer, a treatment that targeted nicotine receptors more than doubled the animals' survival time, a research in Concord suggests. Nicotine plays a dual role in lung cancer. Changes in genes encoding nicotine receptors not only drive the urge the smoke, but also increase susceptibility to lung cancer.

Alexander Winn Kennedy, MD
253 Pleasant St
Concord, NH
Specialties
Oncology (Cancer), Gynecological Oncology
Gender
Male
Education
Medical School: Case Western Reserve Univ Sch Of Med, Cleveland Oh 44106
Graduation Year: 1975

Data Provided by:
Andrew Philip Brown
(603) 230-6100
250 Pleasant St
Concord, NH
Specialty
Radiation Oncology

Data Provided by:
Charles H Catcher
(603) 224-2556
250 Pleasant St
Concord, NH
Specialty
Internal Medicine, Hematology / Oncology

Data Provided by:
Gina M Divenuti
(603) 622-6484
200 Technology Dr
Hooksett, NH
Specialty
Hematology / Oncology

Data Provided by:
Peter H Crow
(603) 622-6484
200 Technology Dr
Hooksett, NH
Specialty
Hematology / Oncology

Data Provided by:
Matthew Strauss Katz, MD
(603) 230-6100
250 Pleasant St
Concord, NH
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Univ Of Ma Med Sch, Worcester Ma 01655
Graduation Year: 1998

Data Provided by:
Matthew Strauss Katz
(603) 230-6100
250 Pleasant St
Concord, NH
Specialty
Radiation Oncology

Data Provided by:
Frederick M Briccetti, MD
(603) 224-2556
250 Pleasant St
Concord, NH
Specialties
Oncology (Cancer)
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
Danny Michael Sims, MD
(603) 622-6484
200 Technology Dr
Hooksett, NH
Specialties
Internal Medicine, Medical Oncology
Gender
Male
Education
Medical School: Emory Univ Sch Of Med, Atlanta Ga 30322
Graduation Year: 1985

Data Provided by:
Charles Howard Catcher, MD
(603) 622-6484
200 Technology Dr
Hooksett, NH
Specialties
Oncology (Cancer), Internal Medicine
Gender
Male
Education
Medical School: Univ Of Mn Med Sch-Minneapolis, Minneapolis Mn 55455
Graduation Year: 1985
Hospital
Hospital: Elliot Hosp, Manchester, Nh; Concord Hosp, Concord, Nh
Group Practice: New Hampshire Oncology-Hmtlgy

Data Provided by:
Data Provided by:

Nicotine Receptors Could Be Lung Cancer Treatment Target

Provided By:

MONDAY, June 15 (HealthDay News) -- In a study of mice with lung cancer, a treatment that targeted nicotine receptors more than doubled the animals' survival time, Italian researchers say.

Nicotine plays a dual role in lung cancer. Changes in genes encoding nicotine receptors not only drive the urge the smoke, but also increase susceptibility to lung cancer. Exposure to nicotine boosts the expression of nicotine receptors, which leads to increased cell proliferation and inhibits the programmed cell death known as apoptosis.

In the new study, published in the June 15 issue of the American Journal of Respiratory and Critical Care Medicine, the compound α-CbT dampened the expression of nicotine receptors and increased apoptosis, prolonging the lives of the mice.

"This research clearly has profound clinical implications regarding the role of nicotine in stimulating lung cancer and nicotine receptor antagonists in treating the disease," said Dr. John Heffner, past president of the American Thoracic Society, in a news release from the society. Heffner, who was not involved in the research, added, "The highly addictive nature of nicotine, however, complicates patients' ability to quit smoking and avoid ongoing nicotine exposure."

Previous research has shown that it's possible to dampen the response of nicotine acetylcholine receptors (nAChRs) using an antagonist called d-tubocurarine/α-Cobratoxin (α-CbT), which specifically targeted the area most linked to increased cell growth.

In the study, researchers grafted human non-small-cell lung carcinoma (NSCLC) onto the lungs of mice and then delayed treatment, allowing the tumors to become well-established.

The mice were then divided into three groups: the untreated group; the standard chemotherapy drug group; and the α-CbT group.

Mice that were categorized as non-obese/severe combined immunodeficient (NOD/SCID) and treated with cisplatin (the standard chemotherapy agent) were found to have a 16 percent longer median survival time than untreated mice. NOD/SCID mice treated with α-CbT had an increased median survival time of 1.7-fold over the cisplatin-treated mice and 2.1-fold over untreated mice.

"The results of this study show that α-CbT, a powerful, high-affinity α-7-nAChR inhibitor, induces antitumor activity against NSCLC by triggering apoptosis," wrote Patrizia Russo of the Lung Cancer Unit of the National Cancer Research Institute in Genoa, Italy, in the news release.

Noncancerous cells did not appear to be affected by α-CbT, suggesting limited toxicity, the researchers found, but they noted that cancer cells with the most receptor binding sites seemed have the greatest treatment sensitivity.

"The goal of this research line is to explore the widest range of possibilities of intervention on the α7-nAChRs," Russo said. "We hope to move further on towards the clinical setting experimentation phase for the assessment of potentially new treatment strategies for NSCLC."

More information

The U.S. National Cancer Institute has more on non-small-cell lung cancer.

SOURCE: American Thoracic Society, news release, June 15, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com

®2010 Hippo Press. site by wedu