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Morphine for Cancer Patients Manchester NH

Two new studies add to growing evidence that morphine and other opiate-based painkillers may promote the growth and spread of cancer cells. The papers, scheduled to be presented Wednesday at an international cancer conference in Boston, also demonstrate how preventing opiates from reaching lung cancer cells reduces cancer cell proliferation, invasion and migration.

Thomas Andrew Sheldon, MD
(603) 669-5300
1 Elliot Way
Manchester, NH
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Tufts Univ Sch Of Med, Boston Ma 02111
Graduation Year: 1980
Hospital
Hospital: Elliot Hosp, Manchester, Nh
Group Practice: New Hampshire Medical Lab

Data Provided by:
Donald Raabe Weiss, MD
(603) 663-1800
1 Elliot Way
Manchester, NH
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Languages
Other
Education
Medical School: Univ Of Co Sch Of Med, Denver Co 80262
Graduation Year: 1965
Hospital
Hospital: St Joseph Hospital And Trauma, Nashua, Nh; Elliot Hosp, Manchester, Nh; Concord Hosp, Concord, Nh; Wentworth-Douglass Hospital, Dover, Nh; Exeter Hosp, Exeter, Nh
Group Practice: Elliot Regional Cancer Ctr

Data Provided by:
Karen Jane Hoffmeister
(603) 629-1827
100 Hitchcock Way
Manchester, NH
Specialty
Hematology / Oncology

Data Provided by:
Gina M Divenuti
(603) 622-6484
200 Technology Dr
Hooksett, NH
Specialty
Hematology / Oncology

Data Provided by:
Danny Michael Sims, MD
(603) 622-6484
200 Technology Dr
Hooksett, NH
Specialties
Internal Medicine, Medical Oncology
Gender
Male
Education
Medical School: Emory Univ Sch Of Med, Atlanta Ga 30322
Graduation Year: 1985

Data Provided by:
Brian Robert Knab
(603) 663-1800
1 Elliot Way
Manchester, NH
Specialty
Radiation Oncology

Data Provided by:
Charles George Leutzinger, MD
(603) 628-1800
1 Elliot Way
Manchester, NH
Specialties
Oncology (Cancer), Radiation Oncology
Gender
Male
Education
Medical School: Univ Of Ct Sch Of Med, Farmington Ct 06032
Graduation Year: 1976

Data Provided by:
Jack Terry Evjy, MD
(978) 685-7811
21 Bowman Parade Rd
Bedford, NH
Specialties
Oncology (Cancer), Hematology-Internal Medicine
Gender
Male
Education
Medical School: Boston Univ Sch Of Med, Boston Ma 02118
Graduation Year: 1961
Hospital
Hospital: Holy Family Hosp And Med Ctr, Methuen, Ma
Group Practice: Commonwealth Hematology-Onclgy

Data Provided by:
Peter H Crow
(603) 622-6484
200 Technology Dr
Hooksett, NH
Specialty
Hematology / Oncology

Data Provided by:
Robert J Friedlander
(603) 622-6484
200 Technology Dr
Hooksett, NH
Specialty
Hematology / Oncology

Data Provided by:
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Morphine for Cancer Patients

Provided By:

WEDNESDAY, Nov. 18 (HealthDay News) -- Two new studies add to growing evidence that morphine and other opiate-based painkillers may promote the growth and spread of cancer cells.

The papers, scheduled to be presented Wednesday at an international cancer conference in Boston, also demonstrate how preventing opiates from reaching lung cancer cells reduces cancer cell proliferation, invasion and migration.

The findings from tests with cell cultures and mice suggest that the mu opiate receptor -- where morphine acts in the body -- may offer a potential treatment target.

"If confirmed clinically, this could change how we do surgical anesthesia for our cancer patients. It also suggests potential new applications for this novel class of drugs which should be explored," Patrick A. Singleton, an assistant professor of medicine at the University of Chicago and principal author of both studies, said in a university news release.

Morphine can increase tumor cell proliferation, inhibit the immune system, promote the growth of new blood vessels (angiogenesis) that feed tumors and decrease barrier function. In cancer patients undergoing surgery, decreased barrier function may make it easier for tumors to invade tissue and spread to other parts of the body, while increased angiogenesis helps tumors thrive in a new location.

Singleton and colleagues found that mice without the mu opiate receptor didn't develop tumors when injected with lung cancer cells, while normal mice did develop cancer. The researchers also found that methylnaltrexone -- developed to treat opiate-induced constipation -- reduced the proliferation of cancer cells in normal mice by 90 percent.

More information

The U.S. National Cancer Institute has more about metastatic cancer.

SOURCE: University of Chicago Medical Center, news release, Nov. 18, 2009

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