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Heartburn Drugs and Blood Thinner Concord NH

Combining the antacid Prilosec with the popular blood thinner Plavix (clopidogrel) can cut the effectiveness of Plavix by half, putting patients at risk for heart attack or stroke, U.S. health officials said Tuesday.

Jeffrey Taylor Lockhart, MD
(603) 224-6070
17 Dwinell Dr
Concord, NH
Specialties
Cardiology
Gender
Male
Education
Medical School: Univ Of Pa Sch Of Med, Philadelphia Pa 19104
Graduation Year: 1981

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Kenneth A DeLoge
(603) 224-6070
246 Pleasant St
Concord, NH
Specialty
Cardiology, Cardiovascular Disease

Data Provided by:
Carl E Levick, MD
(603) 224-6070
246 Pleasant St Ste 103
Concord, NH
Specialties
Cardiology
Gender
Male
Education
Medical School: Univ Of Ma Med Sch, Worcester Ma 01655
Graduation Year: 1978

Data Provided by:
Don P Chan, MD
(603) 224-6070
246 Pleasant St Ste 103
Concord, NH
Specialties
Cardiology
Gender
Male
Education
Medical School: Univ Of Vt Coll Of Med, Burlington Vt 05405
Graduation Year: 1976

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Don P Chan
(603) 224-6070
246 Pleasant St
Concord, NH
Specialty
Cardiology, Cardiovascular Disease

Data Provided by:
Kirke Warren Wheeler, MD
(603) 224-6070
246 Pleasant St Ste 103
Concord, NH
Specialties
Cardiology
Gender
Male
Education
Medical School: Univ Of Rochester Sch Of Med & Dentistry, Rochester Ny 14642
Graduation Year: 1978

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Mark Robert Klinker, MD
(603) 224-6070
246 Pleasant St Ste 103
Concord, NH
Specialties
Cardiology
Gender
Male
Education
Medical School: Tufts Univ Sch Of Med, Boston Ma 02111
Graduation Year: 1985

Data Provided by:
Carl Edward LeVick
(603) 224-6070
246 Pleasant St
Concord, NH
Specialty
Cardiology, Internal Medicine, Cardiovascular Disease

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Patrick F Cassell Jr, MD
(603) 224-6070
246 Pleasant St Ste 103
Concord, NH
Specialties
Cardiology, Critical Care Medicine-Internal Medicine
Gender
Male
Education
Medical School: Georgetown Univ Sch Of Med, Washington Dc 20007
Graduation Year: 1978
Hospital
Hospital: Catholic Med Ctr, Manchester, Nh; Concord Hosp, Concord, Nh
Group Practice: Cardiac Associates Of NH

Data Provided by:
Richard Alan Boss Jr, MD
(603) 226-6106
246 Pleasant St Ste 103
Concord, NH
Specialties
Cardiology
Gender
Male
Education
Medical School: Georgetown Univ Sch Of Med, Washington Dc 20007
Graduation Year: 1978

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Heartburn Drugs and Blood Thinner

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TUESDAY, Nov. 17 (HealthDay News) -- Combining the antacid Prilosec with the popular blood thinner Plavix (clopidogrel) can cut the effectiveness of Plavix by half, putting patients at risk for heart attack or stroke, U.S. health officials said Tuesday.

"These recommendations are based upon recently submitted studies by the manufacturer of clopidogrel [Sanofi-Aventis and Bristol-Myers Squibb]," Mary Ross Southworth, deputy director for safety with the U.S. Food and Drug Administration's Division of Cardiovascular and Renal Products, said during a morning press conference.

"The results of those studies are to avoid the combination of those two medications," she said, adding that the tandem should be avoided even if the two drugs are taken hours apart.

Combining the two drugs is common because Plavix can upset the stomach. The FDA said patients taking Plavix can take alternatives to Prilosec, such as Mylanta, Maalox, or Zantac, Southworth said.

Prilosec is in a class of drugs called proton-pump inhibitors (PPIs). Prilosec was singled out because it was the only PPI tested in studies submitted by the manufacturer of Plavix, Southworth said.

However, proton-pump inhibitors similar to Prilosec -- such as Aciphex, Nexium, Prevacid and Protonix -- should also be avoided when taking Plavix, Southworth said.

Other drugs that may also interact with Plavix, making it less effective include: cimetidine (Tagamet), fluconazole (Diflucan), ketoconazole (Nizoral), voriconazole (Vfend), etravirine, felbamate (Felbatol), fluoxetine (Prozac), fluvoxamine (Luvox), and ticlopidine (Ticlid), according to the FDA.

Results of a study presented Monday at the American Heart Association's annual meeting in Orlando, Fla., also found that people taking the acid reflux drugs Prilosec or Protonix in combination with blood thinners such as Plavix had a higher risk for death after angioplasty than people who didn't take the two popular antacids.

In January, Sanofi and Bristol-Myers updated Plavix's labeling to advise against using it in combination with certain heartburn drugs, the Associated Press reported.

On Tuesday, Sanofi spokeswoman Noelle Boyd said the company had bolstered that language labeling. "We've strengthened the label to say that these drugs should be avoided altogether, not just discouraged," she said.

More information

For more on clopidogrel, visit the U.S. National Library of Medicine.

Author: By Steven Reinberg
HealthDay Reporter

SOURCES: Nov. 17, 2009, teleconference with Mary Ross Southworth, Pharm.D., deputy director for safety, Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration; Associated Press

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